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Data on demographic characteristics, fluid biomarkers, and cardiac-cerebral vascular diseases were collected from medical records. We extracted data using an electronic miniature form in Xijing Hospital affiliated to Air Force Medical University. To be enrolled, participants had to be diagnosed as cerebral infarction and filled out Mini-mental State Examination (MMSE) for cognitive assessment. Participants were older adults aged 65 and above hospitalized from January 2010 to December 2021.
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Identifying outcome determinants could offer clinical insights into cognitive decline, as well as improve prevention strategies considered suitable for clinical use. Hence, our study specifically aims to explore significant risk factors with predictive value for post-cerebral infarction CD diagnosis outcome.
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Given that a variety of factors may initiate or accelerate CD in older adults, developing accurate prediction models is of paramount significance. T2D is of the utmost clinical contributor to the overall burden of CD, and the need to sort out their relationship is a research priority. The evidence as to whether T2D is associated with CD by various mechanisms and pathways is equivocal. There is growing recognition that people of all age groups with type 2 diabetes (T2D) develop progressively cognitive deficits that predominantly occur in older adults, and it is suspected that reduced cerebral vasoreactivity and altered resting cerebral blood flow may account for the lesser grade on cognitive tests. The cognitive domains that showed gradual decline after cerebral infarction, possibly through a synergistic interaction between neurodegeneration and cerebrovascular pathology. Many survivors exhibit cognitive deficits that endure or develop in the years following cerebral infarction, manifesting clinically as a stepwise or fluctuating deterioration in cognition. Insufficient emphasis on CD has been posing a major burden to medical systems and impeding research progress, and there is a critical need for timely prevention.
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Of note, our findings support that the decline in serum direct bilirubin (DBil) concentration is linked to protecting cognitive function.Ĭognitive dysfunction (CD), a major complication of cerebral infarction, appears to take negative effects on the five most commonly assessed domains: memory, attention, calculation, visuospatial function, and executive function. To the best of our knowledge, this study provides a practicable map of strategical predictors to robustly identify cognitive dysfunction at risk of post-cerebral infarction for clinicians in a broad sense. In our pooled dataset from 924 eligible patients, we included 353 in the final analysis (age range 65–91 30.31% female). Collected data referred to Demographic Features, Clinical Diseases, scale tests, fluid biomarkers involving inflammation, coagulation function, hepatorenal function, lipid and glycemic management. Cognitive status was dichotomized into normal cognition and cognitive impairment. Our study recruited inpatients hospitalized with cerebral infarction in Xijing hospital, who underwent cognitive assessment of Mini-Mental State Examination (MMSE) from January 2010 to December 2021. Our research aims to elucidate the significance of type 2 diabetes (T2D) and provides an insight into a novel risk model for post-cerebral infarction cognitive dysfunction (PCICD).